The Service Center Biocatalysis offers screening, enzyme optimization, biocatalyst supply and process development & optimization up to the 500L scale. Together with EC's business line Exclusive Synthesis, large-scale cGMP production is possible.

Screening Capabilities

• HTS-analytics
• Strain collection (>10000 strains)
• Enzyme & clone bank (>100 enzymes)
• Enrichment cultures
• Bioinformatics (gene mining)
• Metagenome screening (together with partner)

Enzyme Optimisation

• various mutagenesis methods established
• high-throughput assays (colorimetric, HT-GC/HPLC)
• robotic systems available (picking, cultivation, assay)
• proven with a number of different enzyme classes
• scalable expression systems

Biocatalyst Supply

• high-throughput fermentation strategies (down-scaling)
• fermenters from 2l to 300l (pilot) and 50 m3 (production)
• scalable high-cell density fermentation protocols
• flexible cell separation: flocculation, batch and continuous centrifugation, ultrafiltration
• cell disruption and purification