History

1951 - Set up of Rexim SA as a trading company: Research Exportation Importation
1961-1965 - S.IC.A.C. (25 persons): extraction of valuable compounds from molasses (Glutamic acid and its sodium salt, betaine)
1965-1977 - Rexim took over the responsibility of the plant to develop its technology in amino acid separation.
1977-1981 - 50% and then 100% ownership by Degussa
1992-1998 - Business focused on pharma intermediates based on amino acids
1996 - ISO 9001 certification by DQS
2000 - First production of an active pharmaceutical ingredient
2001 - Set up of a JV with Nanning Only Time/China
2003 - ISO 14001 certification

Quality standards

• ISO 9001: 2000
• ISO 14001
• Regularly audited by FDA, AFSSaPS, EDQM
• Drug Master files:
  • 19 US DMF
  • 18 E DMF
  • 11 CEP
• Production conforming to cGMP (Q7a)

Equipment

• Manufacturing equipment:
  • chromatographic columns: 100 (from some 10 L up to 30 m3 resin)
• Filtration equipment:
  • filter press: 11 (0,8 to 50 m²)
  • microfiltration (5 to 045 µ and 0.22 µ)
  • ultra filters: 10 (0.6 to 36 m²)
  • reverse osmosis: 1 (110 m² membrane)
• Evaporation equipment:
  • film falling evaporators: 5 (0,5 to 12 metric tons/hour)
  • thin film evaporators: 3 (200 to 1,000 L/hour)
  • NH40H stripping: 1
  • HCl stripping: 1
• Reactors: 30 (300 L to 10 m³/-5 °C to +120 °C/stainless steel and glass lined)
• Centrifuges: 14 (400 to 1,400 mm diameter/stainless steel, halar, hastelloy and rubber coated)
• Dryers:
  • double cone rotating dryers: 3 (250 L to 3 m³/stainless steel and glass lined)
  • turbospheric dryers – mixers: 3 (400 L to 4 m³/stainless steel)
• Mills: 3
• Micronizer: 1
• Clean rooms : 12 (centrifuges, dryers and packaging rooms)